CD47 is a potent “don't eat me” signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages.

The MIAP301 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa 

CD47. CD47, also known as integrin associated protein (IAP) is a transmembrane protein encoded by the CD47 gene in human.It belongs to the  23 Jun 2020 CD47 engagement of SIRPα results in the phosphorylation of cytoplasmic ITIM motifs by inhibitory protein tyrosine phosphatases, SHP-1 and  H89 and protein kinase A (PKA) inhibitor peptide prevented rescue of breast cancer cells by PTX, 8-Br-cAMP, and forskolin, suggesting that the effects of cAMP are  Abstract. Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRPα and  8 Apr 2016 Suppression of MYC in mouse tumors and human tumor cells caused a reduction in the levels of CD47 and PD-L1 messenger RNA and protein. 3 Oct 2016 Methods: MCF-7 breast cancer cells were transfected with plasmid pcDNA3.4- CD47 containing the CD47 gene. The stemness of the transduced  29 Jun 2016 CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alpha (SIRPα), which serves as an  19 Apr 2019 CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3. CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3. It turned out to be associated in cis with integrin αvβ3 on  cytometry.

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Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mice were compared against matching wildtype mice. CD47 (IAP, MER6, OA3) protein expression summary. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occu rs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by … Gene information about ENSG00000196776 / CD47 - CD47 molecule. Gene name.

molecular biology techniques to provide evidence demonstrating the transcription factor alpha-Pal/NRF-1 is a critical regulator of the human IAP/CD47 gene. Blocking cd47/ox101 makes the astrocytes permissive for nerve fiber growth2011Ingår i: Glia: 10th European meeting on Glial Cells in Health and Disease, New  Regulates Iap/Cd47 Expression and Neurite Outgrowth in Neurons: Huang, factor alpha-Pal/NRF-1 is a critical regulator of the human IAP/CD47 gene. Gene Symbol, Annotation, Raw Average WT Counts, Converted WT1 TPM, Converted Cd47, CD47 antigen (Rh-related antigen, integrin-associated signal  52, RP11-74C13.3, Normalizer.

2 Nov 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.

Product Specific Information. Description: The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47  19 Jan 2017 Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.

1995-11-01 · Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).

Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Description of CD47 CRISPR guide RNA. Search for other guide RNAs . The CD47 CRISPR guide RNA sequences shown above were designed by the laboratory of Feng Zhang at the Broad Institute* in order to efficiently target the CD47 gene with minimal risk of off-target Cas9 binding elsewhere in the genome. Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005). NCBI Description of CD47 This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

CD47 molecule (HGNC Symbol) Entrez gene summary. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. By FISH, Lindberg et al. (1994) mapped the CD47 gene to chromosome 3q13.1-q13.2.
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CD47. Gene descriptioni. CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage. Mice were subjected to 90 min middle cerebral artery occlusion.

2020-12-01 · HIF-1 directly bound with the promoter of CD47 to activate gene transcription and increased cell surface CD47 in HCC1954 and SUM159 breast cancer cells . Moreover, macrophage phagocytosis rate was significantly increased when co-cultured with HIF-1-deficient breast cancer cells [ 43 ], indicating that HIF-1 plays a pivotal role in regulation of CD47 expression.
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CD47. CD47, also known as integrin associated protein (IAP) is a transmembrane protein encoded by the CD47 gene in human.It belongs to the 

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets Triple knockout mice do not express the recombination activating gene 2 (Rag2), the CD47 antigen (CD47) gene, or the X-linked interleukin 2 receptor, gamma chain (Il2rg) gene.